Flask is a micro-framework for Python, while Django is a full-stack framework. Flask is lightweight and flexible, giving you more control over components.
Flask is a micro-framework – it provides the essentials (routing, request/response, templates) but leaves many decisions (database, authentication, admin) to the developer. It is designed to be simple and extensible.
Django is a batteries-included framework that comes with an ORM, admin panel, authentication, and many built-in features. It follows a monolithic approach with a strict project structure.
Flask is ideal for small to medium applications, microservices, and when you want to pick and choose your components. Django is better for large, complex applications that benefit from its all-in-one nature.